CBD oil effect

September 24, 2021

How does CBD work?

Science is constantly evolving and we keep learning more about the effect of CBD. At MariPharm we do our own research into these effects. Therefore we are happy to share our knowledge of the effects, efficacy and possible side-effects of CBD oil!


The abbreviation CBD stands for cannabidiol, one of the many ingredients of cannabis. Cannabis contains substances you don’t find anywhere else: these are called (fyto)-cannabinoids. The most well-known cannabinoid is THC, a substance with a psycho-active effect. This makes you high or stoned. The other cannabinoids aren’t psycho-active. This means you can’t get high or stoned from using CBD.


Endocannabinoids can be found throughout the human body. These are substances our bodies produce themselves. Endo means “self”. On a molecular level , these endo-cannabinoids are very similar to cannabinoids from the cannabis plant.

CB-receptors: keys and locks

These endocannabinoids influence our bodies. Think of them as keys that match certain locks. The locks they fit, are the so-called cannabinoid (CB)-receptors. CB means cannabinoid-binding. There are two types of CB-receptors. CB1 receptors are found primarily in the central nervous system, the brain, lungs, muscles, bowels and reproductive organs. CB2 receptors are found primarily in the immune system.


Endocannabinoids and CB-receptors are referred to as the endocannabinoid system (ECS). The ECS is a regulatory system in our bodies, to help maintain homeostasis: regulating and balancing various processes in the human body. It’s responsible for the regulation of processes such as pain perception, mood, digestion, metabolism, and the immune system.

Cannabinoids from the cannabis plant will bind to these CB-receptors as well, like a key will match a lock, because they are so similar to our own endocannabinoids. That is how the cannabinoids from the cannabis plant can contribute to our bodies own processes.

The interaction between CBS and the ECS

Apart from their binding to CB1 and CB2 receptors, CBD will bind to other receptors as well. The exact therapeutical mechanism of CBD is still not completely clear, because it operates through various molecular paths and various different chain-reactions are involved. Lastly, CBD also works as an antagonist of THC and thus diminishes the psycho-active effect of THC.

The interaction between CBD and the ECS possibly influences as many as dozens of different physiological systems and processes in our bodies. There’s a lot of research being done into the exact effects of CBD in the body. In many of these studies, CBD is being linked to, among others:

  • Improved sleep
  • Pain relief
  • Stress reduction
  • Anti-inflammatory effects
  • Anxiety relief

WHO evaluation

In 2018 the World Health Organisation (WHO) released an advisory rapport on CBD. This showed that people tend to respond well to CBD and it’s safe to use. Reported side-effects thus far seem to stem mainly from combining CBD with other medication, according to the WHO.

Possible side-effects

CBD seems to have very few side effects or interactions, but you should always be careful when using different products togethether. It is advised to start with a small dosage of CBD and increase slowly, until you reach your desired effect. This way you’ll also find out what amount of CBD works best for you! We’ll tell you more about that on this page.

Lastly, CBD can alter the effect of other medication. That’s why it’s best to discuss using CBD with your doctor first, if you’re on any type of medication.

Highest possible quality

At MariPharm we adhere to the highest possible quality-standards. This makes it of utmost importance to keep the entire process in-house, from cutting up to the end-product. Even our bottles are of a pharmaceutical standard. On top of that, every batch is tested in our own laboratory, in addition to tests done by a government-approved, independent third party.

Want to know more? Don’t hesitate to ask!

We are happy to help improve people’s lives. Do you want to try CBD oil, but have questions regarding the effects? Please let us know, because we’re more than happy to answer your questions. Know that you can also consult your own physician with any questions you might have.