How does CBD work?
The ‘Endo’ in Endocannabinoids means “self” and are naturally produced compounds found throughout the human body. On a molecular level, these Endocannabinoids are very similar to the cannabinoids found in cannabis plants.
CB-Receptors: Keys and Locks
The way Endocannabinoids influence our bodies is akin to the way keys match certain locks. The ‘locks’ they fit into are so-called cannabinoid binding (CB)-receptors of which there are two types, CB1 and CB2. CB1 receptors are found primarily in the central nervous system, the brain, lungs, muscles, bowels and reproductive organs. CB 2 receptors are found primarily in body’s own the immune system.
The Endocannabinoid System ‘ECS’
Endocannabinoids and CB-receptors are referred to as the ‘Endocannabinoid System’ (‘ECS’), a biological neurotransmission cell-signalling system within the human body that helps maintain homeostasis, which regulates and balances a series of bodily functions, such as pain perception, mood, digestion, metabolism and the immune system.
Cannabinoids from the cannabis plant will bind to these CB-receptors, like a key will fit a certain lock. Because they are so similar to human endocannabinoids, cannabinoids from the cannabis plant can contribute to our bodies’ own regulatory processes.
The Interaction between CBS and the ECS
Apart from binding with CB1 and CB2 receptors, CBD also binds with other receptors. The exact therapeutic mechanism of CBD is still not completely known, because it operates through various molecular pathways involving numerous chain-reactions. CBD is also a THC antagonist and diminishes the psychoactive effects of THC.
The interaction between CBD and the ECS possibly influences as many as dozens of different physiological systems and processes in the human body. Considerable research is being conducted into the exact effects of CBD. Among other things, many studies link CBD to:
• Improved sleep
• Pain relief
• Stress reduction
• Anti-inflammatory effects
• Anxiety relief
In 2018 the World Health Organisation (‘WHO’) released an Advisory Report on CBD showing that it is safe, and people tend to respond well to it. According to the WHO, side-effects thus far seem to stem mainly from combining CBD with medication.
CBD appears to have few side effects or interactions. Nevertheless, it is best to always be cautious when combining different substances. Hence, when you begin with CBD it is always advisable to start with a small dose and slowly increase the dosage, until you achieve the desired effect. This will also enable you to determine the amount of CBD that works best for you! Finally, as CBD can alter the effects of other medication, if you are on any type of medication, consult with your doctor prior to using it.
Highest Quality Possible
At MariPharm we adhere to the highest possible quality-standards, making it vitally important to keep the entire supply chain and production processes in-house, from cultivar to the end-product. Every batch of CBD is tested in our own laboratory, after which they are re-tested by an independent, government-approved third-party laboratory, before being used to fill MariPharm pharmaceutical-grade bottles
If you wish to know more about CBD, please do not hesitate to ask!
We are dedicated to improving the quality people’s lives. Do you want to try CBD oil, but have questions regarding the effects? Please let us know, and we will be more than happy to answer your questions. In addition, you can also seek advice and answers to your questions from your own physician.